Cosmetic Grade Perfume Ambroxane Ambroxan

Ambroxan is a synthetic, ambergris-flavored spice used as a substitute for natural ambergris. Colorless to white crystals. The relative molecular mass is 236.39. The melting point is 75-76°C. The boiling point is 120°C (1.33×102Pa). The flash point is 161°C. Specific rotation -29° (c=1, toluene).

Sclareol is used as a raw material for two-step oxidation, namely alkaline oxidation and weakly acidic oxidation. The oxidant can be potassium permanganate, ozone or potassium dichromate (or sodium) sulfuric acid solution, and then the oxide is saponified. Dehydration and lactonization to obtain ambroxolactone, and then reduce the lactone to ambroxol with lithium aluminum hydride in ether (or use borane in tetrahydrofuran), and use D-camphor-β- Sulfonic acid is used as a cyclizing agent, decyclized to diol, and then dehydrated under the action of aluminum oxide, which can be obtained; (2) Ambroxol is used as raw material through oxidation, reduction and dehydration.
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Natural ambergris is a high-grade spice, which comes from the gray-white soft stones in the stomach of sperm whales, and the amount is very small. Ambergris is a synthetic product. Specific rotation -29 degrees (c=1, toluene)